Empiric Therapy with Aztreonam for Febrile Neutropenic Patients with Hematological Malignancies
نویسندگان
چکیده
منابع مشابه
Antibiotic Rotation for Febrile Neutropenic Patients with Hematological Malignancies: Clinical Significance of Antibiotic Heterogeneity
BACKGROUND Our unit adopted the single administration of cefepime as the initial treatment for febrile episodes in neutropenic patients with hematological malignancies. However, recently, cefepime-resistant gram-negative bacteremia, including those with extended-spectrum β-lactamase (ESBL)-producers, was frequently observed in these patients. Therefore, we instituted a rotation of primary antib...
متن کاملAdequacy of high-dose cefepime regimen in febrile neutropenic patients with hematological malignancies.
While guidelines recommend empirical cefepime therapy in febrile neutropenia, the mortality benefit of cefepime has been controversial. In light of this, recent reports on pharmacokinetic changes for several antibiotics in febrile neutropenia and the consequent suboptimal exposure call for a pharmacokinetic/pharmacodynamic evaluation of current dosing. This study aimed to assess pharmacokinetic...
متن کاملEmpirical voriconazole therapy for febrile neutropenic patients with hematological disorders: a prospective multicenter trial in Japan
An open-label, prospective, multicenter study was conducted between October 2006 and March 2010 to assess the efficacy and safety of intravenous voriconazole (VRCZ) as empirical therapy for antibiotic-refractory febrile neutropenia in Japanese patients with hematological disorders. In addition, to find the patient groups that may benefit from antifungal therapy, the definition of invasive funga...
متن کاملMicafungin compared with caspofungin for the treatment of febrile episodes in neutropenic patients with hematological malignancies: A retrospective study
BACKGROUND Invasive fungal infections are associated with morbidity and mortality in neutropenia secondary to hematological malignancies. Empirical antifungal agents are used to reduce their consequences. Caspofungin is the only echinocandin approved for this indication. Micafungin was compared with caspofungin for the treatment of patients with hematological malignancies and prolonged neutrope...
متن کاملEfficacy and safety of micafungin in febrile neutropenic patients treated for hematological malignancies.
OBJECTIVE The purpose of this study was to prospectively evaluate the efficacy and safety of micafungin (MCFG) in empirical therapy for febrile neutropenic patients for whom antibiotic therapy was not effective for hematological malignancies. PATIENTS AND METHODS Twenty-three hematological patients aged 27-82 years with febrile neutropenia for whom antibiotic therapy was not effective were en...
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ژورنال
عنوان ژورنال: Journal of the Japanese Association for Infectious Diseases
سال: 1989
ISSN: 1884-569X,0387-5911
DOI: 10.11150/kansenshogakuzasshi1970.63.1022